Endocrine Abstracts

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Background: Klinefelter’s syndrome (KS) is a genetic condition affecting men with the potential to severely reduce their testosterone levels and affect their physical appearance. Being a syndrome there are a variety of different symptoms which individuals may experience to a great or lesser extent. While much research has been directed at understanding the cognitive impact of KS much less research has been undertaken considering the psycho-social impact of living with the...

Background: Evidence from a Needs Analysis (2006) and Patient Satisfaction Survey (2008) for people with pituitary conditions, suggested infertility was a key yet unexpected problem for the majority of respondents. Being infertile without the co-morbidity of having a pituitary condition confers a huge emotional burden on the couple concerned. The aim of this study was to explore in detail the effects infertility imposed on people with a pituitary condition.<p class="abstex...

Introduction: The plasma cortisol response to the ACTH test is known to vary significantly by assays. An automated cortisol immunoassays with increased specificity due to the shift from polyclonal to MABs, and standardized against mass spectrometry was recently introduced, with an expected decrease in cortisol concentrations by 20%. Cut-offs used in clinical practice for patient evaluation will thus have to be adjusted. We aimed to assess the normal cortisol response to ACTH s...

Background: In women with autoimmune primary adrenal failure (AD) there is a high prevalence of autoimmune primary ovarian failure (POI). Whether the oophoritis is caused by an unknown ovary-specific autoantibodyor cross-autoimmunity with steroid hormone producing cells in the adrenal cortex is unknown. Autoimmune POI can also affect women without AD. Autoantibodies against steroidogenic enzymes are useful diagnostic markers in AD but are of uncertain value in idiopathic POI.<...

Introduction: Klinefelter’s Syndrome (KS) is a genetic condition affecting men with the potential to severely reduce testosterone levels and affect physical appearance. Being a syndrome there are a variety of different symptoms which individuals may experience to a great or lesser extent. With no screening programme in place, KS may not be detected until puberty, or until men have problems starting a family. As a result, many different healthcare professionals (HCPs) are ...

Objective: To evaluate the long term risk for diabetes and insulin resistance in untreated and oral contraceptive (OC) treated hirsute patients.Design: Cross sectional study.Setting: Academic tertiary-care medical centre.Patients: Of 233 Caucasian hirsute women were evaluated during 1997–2002 (baseline) and re-contacted in 2003–2004. Of 159 patients returned questionnaires and 69 attended clinical e...

Introduction: Fractionated stereotactic radiotherapy (FSRT) is used in the treatment of surgically inaccessible meningiomas, primarily in the base of the skull. Development of hypopituitarism following FSRT is inexhaustively investigated. We aimed to elucidate the cause of hypopituitarism in patients treated with FSRT for benign meningiomas of the anterior skull base.Methods: All patients undergoing FSRT for benign meningioma of the skull base between Ju...

Background: High oxidative stress is associated with increased morbidity. The effect of testosterone treatment (TT) on oxidative stress in ageing men with reduced bioavailable testosterone is undetermined.Aim: To determine the effect of TT compared to placebo on oxidative stress biomarkers.Methods: Double-blinded, placebo-controlled study in 38 men, aged 60–78 years, with bioavailable testosterone <7.3 nmol/l and waist cir...

Objective: Exogenous estradiol increases cortisol binding globulin (CBG) and total cortisol (TC), and therefore it is debated if estradiol supplementation should be paused before evaluation of the adrenal axis. The aim was to evaluate how oral and transdermal estradiol influence TC in hypogonadal women with, or at risk of developing, adrenal insufficiency (AI)Methods: This was a crossover study in 17 women with secondary hypogonadism who were tested with...